The most frequent DNA lesions (8-oxoguanine, thymine glycol, dihydrothymine, dU) (De Bont and van Larebeke, 2014) are removed from the genome by the BER (Kim and Wilson, 2012) (Figure 1). This repair ...
Their work details how cells repair damaged DNA and preserve genes. And now three scientists — Tomas Lindahl, Paul Modrich and Aziz Sancar — have won the 2015 Nobel Prize in Chemistry. Their work ...
A researcher has made a discovery that alters our understanding of how the body's DNA repair process works and may lead to new chemotherapy treatments for cancer and other disorders. Researchers ...
The native structure of genomic DNA can be damaged in many ways, both by external agents and from within the cell as a consequence of normal metabolism In an effort to maintain their genomic integrity ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 11 (Mar. 14, 2006), pp. 4056-4061 (6 pages) DNA-protein crosslinks are relatively common DNA lesions that ...
This is a preview. Log in through your library . Abstract Base excision repair (BER) of DNA damage in irradiated THP1 human leukemic cells was stimulated by pretreating the cells with exogenous ...
In a paper to be published in the Nov. 25 issue of Proceedings of the National Academy of Sciences, the laboratory of cancer geneticist Alfonso Bellacosa, M.D., of Fox Chase Cancer Center reports new ...
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